Nadalia scattered her souls into fragments and influenced the Brume Tower with the idols (Similar to the concept of Phylactery or Horcrux, once all idols are destroyed, then Nadalia herself is destroyed) that have effects such as cursing an area with dark fog, reanimating enemies covered with ash, and healing enemies with Warmth. In order to dispatch them, plunge the Smelter Wedge item into the idols. While doing so you're temporarily invulnerable for a brief second. Highly recommended to go for a suicidal run to purge the cursed rooms since they won't respawn.
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